Enteromegaly and cardiomegaly in Chagas disease
نویسنده
چکیده
EDITORIAL SYNOPSIS Chagas disease due to a trypanosome infection may lead to extensive destruction of ganglion cells in the peripheral autonomic system and may result in gross enlargement of the oesophagus, colon, and heart. From studies on nerve cell counts it is concluded that the number of ganglion cells in the oesophagus must be reduced to less than half to produce functional disturbances in the oesophagus and to one tenth to produce a megaoesophagus. Problems of terminology are discussed.
منابع مشابه
Enteromegaly and Cardiomegaly in Chagas Disease.
Chagas disease due to a trypanosome infection may lead to extensive destruction of ganglion cells in the peripheral autonomic system and may result in gross enlargement of the oesophagus, colon, and heart. From studies on nerve cell counts it is concluded that the number of ganglion cells in the oesophagus must be reduced to less than half to produce functional disturbances in the oesophagus an...
متن کاملIn vitro Anti-epimastigote Activity of some Iranian Medicinal Plants
Some medicinal plants are a potential source of new drugs, in order to improve the treatment of Chagas disease whose treatment is still a challenge. In this study, the in vitro anti-epimastigote activity of certain fractions of Achillea biebersteinii, A. millefolium, Satureja mutica and S. macrantha was evaluated. Diethyl ether fractions of Achillea species and acetone fractions of Satureja spe...
متن کاملCarlos Chagas Discoveries as a Drop Back to Scientific Construction of Chronic Chagas Heart Disease
The scientific construction of chronic Chagas heart disease (CCHD) started in 1910 when Carlos Chagas highlighted the presence of cardiac arrhythmia during physical examination of patients with chronic Chagas disease, and described a case of heart failure associated with myocardial inflammation and nests of parasites at autopsy. He described sudden cardiac death associated with arrhythmias in 1...
متن کاملPredictors of mortality in chronic Chagas disease: a systematic review of observational studies.
BACKGROUND Chagas disease is a major cause of morbidity and mortality in Latin America. Knowledge of the predictors of prognosis can help clinical decision making by identifying patients' level of risk. METHODS AND RESULTS We reviewed the published literature on prognostic factors in patients with Chagas disease by performing a PubMed search for articles published in any language between 1985...
متن کاملEffect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model
The dog is considered the main domestic reservoir for Trypanosoma cruzi infection and a suitable experimental animal model to study the pathological changes during the course of Chagas disease (CD). Vaccine development is one of CD prevention methods to protect people at risk. Two plasmids containing genes encoding a trans-sialidase protein (TcSP) and an amastigote-specific glycoprotein (TcSSP4...
متن کامل